Genetic Engineering and Diseases – Gene Drive & Malaria

  • Published: 21 September 2016
  • We have the choice to attack one of our oldest enemies with genetic engineering. But should we do it?

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    Big thanks to James Gurney and Roya Haghighat-Khah for their help and advice with this video!


    Lucien Delbert, Mike C, Ricardo Chavarria, Juha Wellman, Zachary Jordan, Patrick Chang, Adrian Mihali, Nicodemos Nicodemou, Lacey Larson, Austin Earnest, Andre Wee, Koroslak, Alex Brady, Roberto Cano, Andreas Stokholm, Plamen Ivanov, E Smith, Kieran Hunter-East, Christopher Trinh, Tony Kwok, Adam Rabenstein, Andrew Whitehurst, Alena Vlachova, Mackenzie Broadbent, Andreas Hertle, Martin Petersen, Kasturi Raghavan, Gregory Griffin, KiaTheDead, Aaron Stevens, Jimmy C, Benedikt Jaletzke, Jonathan Bowler, Zdravko Šašek, Wouter Stokhof, Zealotus, Long Vu, Fatman13, Jeremy Dumet, Miles Spoor, Mirton I, Al Fl, Jonathan Carter, Stanislaw Wasowicz, Marek Turcani, Francisco Santos, Justin Choi, Dagoberto Chapa, Chip Salzenberg, TinFung, Bob Bergeron, Peer, Justin Elstrott, Rachid Malik, Octavio Astillo, Romain Isnel, Rich Sekmistrz, Kuosora, Mozart Petter, Justin Jeffries, Nicola Licheri, Bahram Malaekeh, Florent Petterschmitt, David Mark, Gaby Germanos, Shweta Bharadwai, Lux Stamm, Marc Johann, Joe, Nefaur Khandker, Anders Madsen, Sarah Yoshi, monoxide, Brandon Meador, Dovydas Bartkevicius, Tyler Vigen, Michael Niella, Gordon Timilty, Slava Dzyba, Bagel Krippen Chandra, KodinCage, Miikka Harjuntausta, Magid Elgady, Vince Houmes, Irae Carvalho, Josh Talbot, Mr.Z, Pawel Urbanek, Russ Clarke, Lucas Tostes, Oscar Chamaria, Zachary Langdon, Steve Bollenbaugh, Xiaogiang Zheng, Peter LoPinto, Jenny Nordenborg, Evan Faas, Greg Fowler, Cicmil Mladen, Canut Durgun, Malovich, Cedric, Dave Anderson, Jones, Elliot, Denis Dube, David Allen, Dawson Reid, Jake Zwirdowski, Denis Leu


    Harvard FAQs on gene drive:

    Research paper on using CRISPR for malaria gene drive:

    Nature article on engineered mosquitos:

    STAT new article on using gene drive against Zika:

    Tech review article on using gene drive against malaria:

    Smithsonian on deadliness of mosquitos:

    Science article about the risks of the technology:

    New Yorker on Pros and Cons:

    Gates note on death rate through mosquitos:

    Status quo on field trial in the U.S.:

    Evolution working against gene drive technology:

    Research paper on evolution of resistance against gene drive:

    Science news on possible safety feature for gene drive:

    Help us caption & translate this video!

Comments • 18 266

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    • Austin Smith
      Austin Smith  2 days back

      I think this debate may be one of the great filters discussed in another video. Either we're supposed to genetically engineer disease carrying creatures to be immune in order to progress as a dominant race, or it backfires against us and wipes us out. This is one of the filters.

    • Rejjaqul Hasnat
      Rejjaqul Hasnat  1 weeks back

      What if plasmodium develops resistance against the antibodies?

    • Maxi Immortality
      Maxi Immortality  2 months back


    • Polly Huang
      Polly Huang  4 months back

      Do it mofo

  • Soren Robitaille
    Soren Robitaille  11 hours back

    5:19 -looks at fly- sleeping sickness? OH HELL NO *SWIGGITY SwOOGITY*

    • jace northern
      jace northern  18 hours back

      oh no

      • Unknown hope
        Unknown hope  22 hours back


        • axellexious
          axellexious  2 days back

          Damn, having dengue is no joke, 3 times i was inflicted with that sht, 3rd one was the worst.

          So yeah fck mosquitoes, hope they all die

          • Robert Dennison
            Robert Dennison  2 days back

            I feel like we undervalue the population control disease provides. If this truly eradicates malaria people will live longer and in higher numbers. I'm not sure if any of you have realized how crowded it is here already.

            • Pdog 10
              Pdog 10  2 days back

              Humans dont have predetors and what maleria kills billions.Nah.

              • orso territoriale
                orso territoriale  3 days back

                mosquito: *bites me*

                me: *bites mosquito*

                • aryana love
                  aryana love  3 days back

                  Just throw out 1000000000000000000000000000000000000 birds

                  • Mr. Bern
                    Mr. Bern  3 days back

                    This type of technology is the equivalent of Dark Magic in any fantasy story. It can be used for good, but the chances of it being used for evil or turning out incredibly bad are way too high.

                    Conclusion: If you're going to use it, you better know what you're doing, how you're doing it and be prepared to fight off unwanted consequences.

                    • Oliver Zhang
                      Oliver Zhang  4 days back

                      The Great Filter?! A parasite taxi drives the species extinct?

                      • Oliver Zhang
                        Oliver Zhang  4 days back

                        Just random thing, the newspaper at 5:33 is $2.97. sqrt 2 to the power of π is e^π which is $2.97068642353, which rounds to $2.97.

                        • Y M
                          Y M  4 days back


                          • Y M
                            Y M  4 days back

                            Mosquitos are like the mutos in Godzilla 2014

                            • Bernardo Gouvea
                              Bernardo Gouvea  4 days back

                              This has to be applied together with the education of the population, especially those living in tropical forests. For the planet's population is increasing even with fatal diseases. Without them people have to know how to use contraceptive methods. Otherwise the population will grow at a faster rate.

                              • spaceflight Simulator
                                spaceflight Simulator  4 days back

                                Do it

                                • Golbstalker Z
                                  Golbstalker Z  5 days back

                                  we should not use gene editing on mass scale, it's better if WE adapt to become stronger and more immune. otherwise I think zombie apocalypse will be the consequence of crispr

                                  • Stefen Fuqua
                                    Stefen Fuqua  5 days back

                                    Why are mosquitoes such good damn vectors?

                                    • DamnStupidOldIdiot
                                      DamnStupidOldIdiot  5 days back

                                      Malaria really only affects people in poorer places like Africa, unfortunately, so they don't really have much they can do, sure bed nets are a thing but you do have to go outside.

                                      • Steven Schulte
                                        Steven Schulte  6 days back

                                        Yep do it

                                        • spino tv
                                          spino tv  7 days back

                                          Pls do video about zombie deers

                                          • Julian Aguirre
                                            Julian Aguirre  7 days back

                                            God I just love that intro.

                                            • Veronika Tushynska
                                              Veronika Tushynska  1 weeks back

                                              Use it! Use it!😠 use it! Use it!😠

                                              • Pepe The Dead Frog
                                                Pepe The Dead Frog  1 weeks back

                                                Elon Musketo has entered the chat

                                                • Jacky Saids Oh Yeah Yeah


                                                  Random scientist: I'll risk my life for the cure.

                                                  • toast fangirl draws
                                                    toast fangirl draws  1 weeks back

                                                    I have a tip not to get bittin:

                                                    *Don't go outside*

                                                    • Kamelskih
                                                      Kamelskih  1 weeks back

                                                      What I think? TAKE THIS FEATH SWORD!

                                                      • 김기민
                                                        김기민  1 weeks back

                                                        Excuse me. Can I use this video for school?

                                                        • Matt Matt
                                                          Matt Matt  1 weeks back

                                                          We sholuld do it

                                                          • Will Overdeck
                                                            Will Overdeck  1 weeks back

                                                            The mighty

                                                            • Christopher Morey
                                                              Christopher Morey  1 weeks back

                                                              or nuke all mosquitos

                                                              • Christopher Morey
                                                                Christopher Morey  1 weeks back

                                                                OMG yeetsquitos

                                                                • 《Tree - The puno family》

                                                                  Me: sprays insecticide around the house while watching this

                                                                  • Elizabeth Choo
                                                                    Elizabeth Choo  1 weeks back

                                                                    CRISPR! we need no malaria!

                                                                    • Jonathan Davis
                                                                      Jonathan Davis  2 weeks back

                                                                      Not a single bird dies for once

                                                                      • aEsthEtic ViBes
                                                                        aEsthEtic ViBes  2 weeks back




                                                                        • Matthew Torres
                                                                          Matthew Torres  2 weeks back

                                                                          What if, mosquitoes are the key for killing HIV Virus?

                                                                          • C. McMenemy
                                                                            C. McMenemy  2 weeks back

                                                                            1000 dead children every day and here we are making jokes

                                                                            • Született Gamer
                                                                              Született Gamer  2 weeks back

                                                                              Multiplying and the bursting out of cells?....




                                                                              • Jake Hewitt
                                                                                Jake Hewitt  2 weeks back

                                                                                I honestly think we should wipe out mosquitoes. It'll kill those diseases off, and make going to tropical places less of a pain.

                                                                                • SavageBoi
                                                                                  SavageBoi  2 weeks back

                                                                                  We need mosquitoes to kill us off so the environment will be saved lol

                                                                                  • Marco Biddau
                                                                                    Marco Biddau  2 weeks back

                                                                                    Yes, genetically modifying mosquitoes is a hazard for the environment. But you know how Malaria was eradicated from certain areas (see Sardinia)? With tons of DDT! A 'gentle' insecticide that exterminates all insect life and is still present nowadays in penguins in the south pole! Maybe is worth making small scale experimentation of modified mosquitoes. BTW, very nice video from a malariologist point of view! I would have just added a gametocyte stage between the human and the mosquito.

                                                                                    • Flaky 96
                                                                                      Flaky 96  2 weeks back

                                                                                      Watching these vids by "In a nutshell" makes me realize how smart viruses are, they sound lile living organisms, hide themselves, disguise as other cells, invade, trick the cells, eat cells, manipulate, gosh, and the smartest ones are deadliest enemies that are smarter and stronger than our body

                                                                                      • MegalodoN
                                                                                        MegalodoN  2 weeks back

                                                                                        Error 404

                                                                                        *_malaria not found in file “2020”_*

                                                                                        • Lawrence Gaming
                                                                                          Lawrence Gaming  2 weeks back

                                                                                          Can we make thanos using crispr?

                                                                                          • Cindy Griffith
                                                                                            Cindy Griffith  2 weeks back

                                                                                            Reply anti anti ethical if it should be used

                                                                                          • Dinh Dover
                                                                                            Dinh Dover  2 weeks back

                                                                                            We solve the malaria problem, Nature finds another method to thin out the heard.
                                                                                            We CURE EVERYTHING!
                                                                                            Over population DESTROYS the planet and Earth starts over again, we're also a parasite that EARTH is trying to cure (get rid of).

                                                                                            • Трофим Ушаков

                                                                                              We need to create absolutely isolated copy of our ecosystem and modified mosquitos there and look what will happen.